Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm. J. Immunol. 2000. 164: 6166–6173
نویسندگان
چکیده
منابع مشابه
J Immunol
Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of RA in Th17/regulatory T cell generation in vivo, we generated vitamin A-deficient (VAD) mice by c...
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Evidence is provided that macrophages can make M-1 or M-2 responses. The concept of M-1/M-2 fomented from observations that macrophages from prototypical Th1 strains (C57BL/6, B10D2) are more easily activated to produce NO with either IFN-gamma or LPS than macrophages from Th2 strains (BALB/c, DBA/2). In marked contrast, LPS stimulates Th2, but not Th1, macrophages to increase arginine metaboli...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2017
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1701141